opentargets-database

# Open Targets Database ## Overview The Open Targets Platform is a comprehensive resource for systematic identification and prioritization of potential therapeutic drug targets. It integrates publicly available datasets including human genetics, omics, literature, and chemical data to build and score target-disease associations. **Key capabilities:** - Query target (gene) annotations including tractability, safety, expression - Search for disease-target associations with evidence scores - Retrieve evidence from multiple data types (genetics, pathways, literature, etc.) - Find known drugs for diseases and their mechanisms - Access drug information including clinical trial phases and adverse events - Evaluate target druggability and therapeutic potential **Data access:** The platform provides a GraphQL API, web interface, data downloads, and Google BigQuery access. This skill focuses on the GraphQL API for programmatic access. ## When to Use This Skill This skill should be used when: - **Target discovery:** Finding potential therapeutic targets for a disease - **Target assessment:** Evaluating tractability, safety, and druggability of genes - **Evidence gathering:** Retrieving supporting evidence for target-disease associations - **Drug repurposing:** Identifying existing drugs that could be repurposed for new indications - **Competitive intelligence:** Understanding clinical precedence and drug development landscape - **Target prioritization:** Ranking targets based on ...