trial-readout-analysis

> Methodology inspired by publicly taught clinical-trial frameworks; all text is an original paraphrase. ## Defaults | Parameter | Default Value | Rationale | |-----------|---------------|-----------| | scrutiny_axes | all six + tolerability | Safety/stats/subgroups/missing data/endpoints/benefit-risk + tolerability/persistence as co-equal axis | | lattice_comparators | SoC + class peers | Every readout is placed against standard of care and same-class peers | | safety_imbalance | defer to outcomes | Small-N safety imbalances defer the verdict to a larger outcomes trial | | conflict_policy | materiality-rated | Conflicting readings surfaced verbatim, rated by materiality or deferred | | outcome_framing | base/bull/bear | Binary readouts need scenario sizing | | reaction_context | historical cases | Size moves from past analogues | ## Preflight Run canonical pre-flight per `contracts/preflight.md`. Include the `X-Agentii-Trace` header on every tool call per `contracts/x-agentii-trace-header.md` — carry the `_run_id` from your first tool result and name yourself (and your parent, if you were spawned). ## Triggers - "Evaluate [ticker]'s upcoming trial readout." - "What should I look for in [trial]'s data?" - "Size the readout for [drug] phase 3." - "What did the AdCom-style scrutiny say about similar trials?" - "Base/bull/bear for [ticker]'s readout." - "Which endpoints matter for [trial]?" - "How has the market reacted to similar readouts?" - "Readout checklist for [ticke...