mageck-crispr-analyzer

# MAGeCK CRISPR Analyzer Skill ## Purpose Provide MAGeCK CRISPR screen analysis for gene essentiality scoring. ## Capabilities - Guide read counting - Normalization and QC - Gene-level analysis - Pathway enrichment - MLE model for complex designs - Visualization outputs ## Usage Guidelines - Count guides accurately from sequencing data - Normalize counts appropriately - Calculate gene-level scores - Enrich for biological pathways - Use MLE for complex experimental designs - Generate informative visualizations ## Dependencies - MAGeCK - BAGEL - CRISPResso2 ## Process Integration - CRISPR Screen Analysis (crispr-screen-analysis)