drug-encapsulation-optimizer

# Drug Encapsulation Optimizer ## Purpose The Drug Encapsulation Optimizer skill provides systematic optimization of nanoparticle drug delivery formulations, enabling maximized drug loading, controlled release kinetics, and formulation stability. ## Capabilities - Drug loading optimization - Encapsulation efficiency calculation - Release kinetics modeling (zero-order, Higuchi, Korsmeyer-Peppas) - Stability testing protocols - Size optimization for target application - Payload-to-carrier ratio optimization ## Usage Guidelines ### Formulation Optimization 1. **Loading Optimization** - Screen loading methods - Optimize drug:carrier ratio - Maximize encapsulation efficiency 2. **Release Kinetics** - Characterize release profile - Fit to kinetic models - Design sustained release 3. **Stability Assessment** - Monitor size over time - Track drug leakage - Accelerated stability testing ## Process Integration - Nanoparticle Drug Delivery System Development - Nanomaterial Safety Assessment Pipeline ## Input Schema ```json { "drug": "string", "carrier_type": "liposome|polymer|micelle|lipid_np", "target_loading": "number (wt%)", "release_target": "immediate|sustained|triggered", "route": "iv|oral|topical|inhalation" } ``` ## Output Schema ```json { "optimized_formulation": { "drug_loading": "number (wt%)", "encapsulation_efficiency": "number (%)", "particle_size": "number (nm)", "pdi": "number" }, "release_kinetics...