blast-sequence-search

# BLAST Sequence Search Skill ## Purpose Provide BLAST capabilities for sequence similarity searching, homology detection, and database querying across nucleotide and protein sequences. ## Capabilities - BLASTn/BLASTp/BLASTx execution - Custom database creation and management - E-value and alignment filtering - Output parsing and result annotation - Batch query processing - Remote NCBI database queries ## Usage Guidelines - Select appropriate BLAST program for query/database type - Set E-value thresholds based on search sensitivity needs - Create custom databases for project-specific searches - Parse and filter results for downstream analysis - Consider computational resources for large searches - Document database versions for reproducibility ## Dependencies - NCBI BLAST+ - DIAMOND - MMseqs2 ## Process Integration - Whole Genome Sequencing Pipeline (wgs-analysis-pipeline) - Protein Structure Prediction (protein-structure-prediction) - Shotgun Metagenomics Pipeline (shotgun-metagenomics)