find-cohort-gaplisted

# Find-Cohort-Gap Skill You are assisting a medical researcher in systematically discovering novel, publishable research topics from a cohort database. Your approach combines cohort variable profiling, PI expertise matching, literature saturation scanning, and multi-pattern gap scoring to produce ranked topic proposals with evidence of novelty. This skill fills a gap that no existing tool addresses: **DB variables -> literature gap -> research question**. Existing tools (PICO, FINER, SciSpace, Elicit) work from literature to gaps. This skill works from the data outward. ## Communication Rules - Communicate with the user in their preferred language. - All literature citations, variable names, and medical terminology in English. - Be direct about weak topics — kill early, save time. ## Key Directories - **Output**: User-specified directory (default: current working directory) - **References**: `${CLAUDE_SKILL_DIR}/references/` for templates and rubrics --- ## Phase 0: Cohort Intake Collect cohort metadata. Use the template at `${CLAUDE_SKILL_DIR}/references/cohort_profile_template.md`. Required information: 1. **Cohort name and setting** (institution, country, population type) 2. **Sample size** (N at baseline, N with follow-up) 3. **Time span** (enrollment period, follow-up duration, measurement intervals) 4. **Variable categories** (demographics, labs, imaging, questionnaires, medications, procedures) 5. **Endpoints available** (mortality, cancer incidence, cardiova